The aim of the present work is to understand the effect of low dose of hydroxyurea (HU) therapy on oxidative damage of RBC
membrane in non-transfused Eβ thalassaemia. HU was administered at a dose of 30 mg/kg/day for 90 consecutive days. The percentage
of spectrin and the level of malondialdehyde (MDA), fetal hemoglobin (HbF), hemoglobin (Hb) and packed cell volume (PCV) were
measured. The HbF level was significantly increased after 90 days of HU therapy. MDA level of RBC membrane was decreased.
There was no change in PCV, Hb and spectrin content of RBC membrane after HU therapy for 90 days in Eβ thalassaemia. Increment
of HbF in HU treated Eβ patient may have some role on the correction of oxidative damage of RBC membrane by inhibiting further
degradation of spectrin and by decreasing lipid peroxidation of red cell membrane. 相似文献
In this study, the reasoning of students, who are introduced to the concept of chemical equilibrium, was related to the historical
development of this concept. In the first stage of the study, remarkable similarities were observed between students' reasoning
on the issue of incomplete chemical conversions and the reasoning of 19th-century scientists, especially when molecular notions
were included. In the next stage of the study, some authentic problems and questions, that were essential in the historical
development of chemical equilibrium, were presented to students. It appeared that they recognised the significance of these
problems and questions. Moreover, most students were eager to find explanations. Students, reasoning in molecular terms, would
sometimes explain these problems in terms similar to historical explanations. Other students, however, suggested explanations
in non-molecular terms, which, although chemically valid, did not appear to have historical antecedents. It was concluded
that the study of authentic historical sources may inspire the design of effective teaching activities. 相似文献
Research and design activities are important focus points in international policies for secondary Science, Technology, Engineering and Mathematics (STEM) education. It is up to school teachers to implement and supervise these activities in the STEM classroom. However, not much is known about the attitudes teachers hold towards supervising research projects or design projects. In this study, a questionnaire to measure teacher attitudes towards supervising research activities and design activities in secondary school was completed by 130 Dutch teachers who taught the relatively new Dutch STEM subjects O&O (research and design) and NLT (nature, life, and technology). These integrated STEM subjects are project and context based and are taught in a limited number of schools. Important differences between these integrated STEM subjects are their student and teacher populations: NLT is taught in grades 10–12 by teachers with a qualification in a science subject, while O&O is taught in grades 7–12 and can be given by any teacher in secondary school. The results showed that on average, both O&O and NLT teachers had high self-efficacy scores on supervising research and design projects even when they had received no special education in doing so. Furthermore, the teachers in general viewed supervising research projects as a more relevant activity than supervising design. Since research and design activities are becoming more important in (inter)national curriculum standards, STEM teacher education and subsequent professional development should not only familiarize teachers with supervising research projects, but with design projects as well.
This article aims to analyse the disciplinary procedures brought against public schoolteachers in Galicia from 1859 until 1910. The article starts with the presentation of the legal basis for the government inquiries and the administrative framework in which they were implemented. Following is an examination of the evolution of the inquiries, the origin of the complaints, the charges filed against the teachers and the sanctions proposed. Lastly some examples are provided of the most widespread offences, consisting of abandonment of teaching as well as other charges of moral misconduct such as cohabitation and sexual abuse of the children. 相似文献
Metacognition and Learning - When compared to high performers, low performers generally have more difficulty to accurately estimate their own performance. This has been explained by low performers... 相似文献
The rapid expansion of Big Data Analytics is forcing companies to rethink their Human Resource (HR) needs. However, at the same time, it is unclear which types of job roles and skills constitute this area. To this end, this study pursues to drive clarity across the heterogeneous nature of skills required in Big Data professions, by analyzing a large amount of real-world job posts published online. More precisely we: 1) identify four Big Data ‘job families’; 2) recognize nine homogeneous groups of Big Data skills (skill sets) that are being demanded by companies; 3) characterize each job family with the appropriate level of competence required within each Big Data skill set. We propose a novel, semi-automated, fully replicable, analytical methodology based on a combination of machine learning algorithms and expert judgement. Our analysis leverages a significant amount of online job posts, obtained through web scraping, to generate an intelligible classification of job roles and skill sets. The results can support business leaders and HR managers in establishing clear strategies for the acquisition and the development of the right skills needed to leverage Big Data at best. Moreover, the structured classification of job families and skill sets will help establish a common dictionary to be used by HR recruiters and education providers, so that supply and demand can more effectively meet in the job marketplace. 相似文献